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Developed by Ivy Surrogacy, this calculator estimates the likelihood that each embryo is euploid based on maternal age, blastocyst day (D5–D7), and morphology grade — helping you interpret your PGT-A results with clarity and confidence.
This calculator estimates the likelihood that an embryo is chromosomally normal (euploid) using three main factors derived from large PGT-A datasets:
Euploidy rates decline with age — about 68% for ≤30 years, 58% for ages 31–34, 50% for 35–37, 35% for 38–40, 22% for 41–42, and 16% for ≥43.
Embryos that reach blastocyst earlier tend to be more chromosomally normal:
Day 5 ×1.00, Day 6 ×0.80, Day 7 ×0.50.
Embryos with stronger ICM and TE quality have higher euploid chances:
AA ×1.15, AB/BA ×1.10, BB ×1.00, BC/CB ×0.75, CC ×0.55.
Euploid Probability = Age Baseline × Day Multiplier × Morphology Multiplier
(Results constrained between 5%–85%, with total probability capped at 99%.)
Shows the average number of embryos likely to be chromosomally normal.
Example: If six embryos are entered and the total is 3.2, about three may be euploid.
Reflects the likelihood that at least one embryo in your set is chromosomally normal.
Even with multiple embryos, this probability is capped at 99% to avoid implying absolute certainty.
Each embryo’s result depends on its age band, development day, and morphology combination.
Day 5 AA embryos in younger age bands show the highest predicted probabilities.
While the model is based on large PGT-A datasets, these estimates are meant for educational reference only.
Each individual’s biology, lab conditions, and clinical context may differ, resulting in natural variability beyond statistical prediction.
The PGT-A Euploid Probability Calculator is built upon decades of reproductive genetics research and thousands of tested embryos across U.S. fertility centers. It reflects how three biological mechanisms—maternal age, embryo developmental timing, and morphological quality—interact to determine chromosomal normality.
As maternal age increases, the quality of oocytes declines due to cumulative damage in the meiotic spindle and mitochondrial function. Chromosome-segregation errors during meiosis I become more frequent, leading to higher rates of aneuploid embryos.
In women under 30, about two-thirds of embryos are chromosomally normal; by 40, that number drops to roughly one-third, and by 43 and beyond, to less than one in five. This age-related decline forms the baseline of the model.
Embryos that reach the blastocyst stage earlier (Day 5) usually have stronger metabolic efficiency, better genomic activation, and lower cellular stress. Delayed development (Day 6 or 7) may indicate chromosomal imbalance or suboptimal cellular energy, resulting in a reduced chance of being euploid. Studies consistently show a stepwise decline in euploid rates from D5 → D6 → D7.
Blastocyst morphology grading—based on the quality of the inner cell mass (ICM) and trophectoderm (TE)—is a visual proxy for cellular organization and genome stability. Embryos with compact ICM and cohesive TE layers (grades AA–AB–BA) demonstrate lower DNA-damage rates and better chromosomal integrity. Conversely, embryos with loose or sparse TE (BC, CC) tend to show more fragmentation and abnormal division patterns.
Together, these three predictors explain most of the variation observed in chromosomal outcomes after IVF and form the foundation of the calculator’s probability model.
PGT-A testing identifies which embryos are chromosomally normal, but the next question is:
What is the chance of achieving a live birth from a euploid transfer?
Use our complementary Embryo Transfer Success Rate Calculator to estimate your expected live birth probability per transfer based on PGT-A results, blastocyst day, and maternal age.
These two calculators together provide a complete view:
PGT-A Calculator: Predicts which embryos are likely chromosomally normal.
Transfer Success Calculator: Estimates how likely those embryos are to result in a live birth.
Find clear answers to common questions about PGT-A results, embryo euploid probability, and IVF outcomes.
Yes. Select the age band of the egg provider (donor) rather than the recipient. Chromosomal competence is determined by the egg source, not by the uterus or gestational carrier. This ensures your euploid probability estimate remains medically accurate.
These indicate the day an embryo reached the blastocyst stage after fertilization. Embryos that form blastocysts earlier (Day 5) generally have higher euploid probability, while Day 6 and Day 7 embryos often show slower development and slightly lower chromosomal stability.
Morphology grading evaluates the inner cell mass (ICM) and trophectoderm (TE) quality. High-quality embryos (AA, AB, BA) have more organized cellular structure and greater genome stability, whereas lower grades (BC, CC) are more prone to fragmentation or abnormal division—hence, lower euploid probability.
No. A euploid embryo has the correct number of chromosomes, but implantation and live-birth outcomes depend on additional factors such as uterine environment, hormonal balance, embryo transfer technique, and overall maternal health.
To reflect biological variability and laboratory uncertainty. Even when conditions are optimal, real-world data show that no scenario can offer absolute certainty—so probabilities are capped at 99% for scientific realism.
Most genetics laboratories provide results within 10 to 14 days after biopsy. Turnaround time may vary slightly between IVF clinics, testing platforms, and workflow schedules.
This model is based on large multicenter datasets and validated research, but it provides an educational estimate only. Individual outcomes can vary due to differences in ovarian response, egg quality, lab conditions, and biopsy methods. Use it as a guide—not a guarantee—to inform discussion with your fertility specialist.
Discover our free, medically informed calculators to plan your IVF and pregnancy journey.
Estimate euploid likelihood using age and blastocyst development data.
Age, blastocyst day (D5–D7), and morphology combined for live-birth odds.
Get EDD from LMP or embryo transfer day — IVF-friendly.
Personalized targets by pre-pregnancy BMI for singleton/twins.
Auto unit conversion with standard BMI categories.
Feet/inches ⇄ centimeters, pounds ⇄ kilograms — no math.
⚠️ Disclaimer: This calculator is for educational and informational purposes only. It is not intended to diagnose or treat any medical condition. For personalized medical advice, always consult your physician, OB-GYN, or midwife.
